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Fig. 5 | Retrovirology

Fig. 5

From: Dysregulation of the tumor suppressor Menin and its target Bach2 in HTLV-1 infection

Fig. 5

Knockdown of HTLV-1 Tax by shRNA results in decrease of Bach2 but not Menin protein in HTLV-1-infected T-cell lines. Tax- or HBZ-directed shRNAs in HTLV-1-infected T cell lines showed opposite effects on cell growth by the Menin-MLL interaction inhibitor. The shRNA knockdown of HBZ did not change the expression levels of either Menin and Bach2 in SLB-1 and MT-2 cells (A), whereas the shRNA knockdown of Tax suppressed the expression levels of Bach2 but not Menin in SLB-1 and MT-2 cells (B)

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Retrovirology

ISSN: 1742-4690

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