Fig. 11
From: Biomolecular condensates: insights into early and late steps of the HIV-1 replication cycle
Intrinsic disorder and phase separation propensity of 4792 human proteins interacting with all HIV-1 proteins. A pLLPS vs. PONDR® VSL2 disorder score dependence. In these analyses, proteins with pLLPS ≥ 0.6 are expected to serve as LLPS drivers, whereas proteins with the disorder scores ≥ 0.5 are predicted as mostly disordered. Among the 4792 human proteins interacting with all HIV-1 proteins, 1738 proteins (36.27%) are expected to be mostly disordered, and 1669 (34.83%) are expected to serve as LLPS drivers. Among the LLPS drivers, 655 proteins (39.24%) are mostly disordered, indicating that 13.67% of HIV-1-interactors are mostly disordered proteins driving LLPS. B Dependence of the pLLPS on the percent of disordered residues predicted by PONDR® VSL2. Proteins with pLLPS ≥ 0.6 are expected to serve as LLPS drivers, whereas proteins with the PPIDR ≥ 30% are predicted as highly disordered. Based on the outputs of these analyses, 2820 human proteins from HIV-1 interactome (58.84%) are expected to be highly disordered. Among 1669 of LLPS drivers, 1038 proteins (62.19%) are expected to be highly disordered, indicating that 21.66% of HIV-1-interactors are highly disordered LLPS drivers