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Table 2 The association between SERINC5 down-regulation and rate of CD4 + T cell decline

From: HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Univariable (n = 101)

Multivariable (n = 101)

Variable

Coeff.

SE

p value

Variable

Coeff.

SE

p value

SERINC5a

 − 6.79

4.7

0.15

SERINC5

 − 3.35

4.46

0.45

    

Square-root baseline CD4b

 − 0.99

0.24

 < 0.0001

    

Follow-up timec

0.01

0.002

 < 0.0001

    

Log baseline viral loadd

 − 1.03

0.9

0.25

    

Cohorte: Tshedimoso

0.35

2.73

0.9

    

TRAPS

 − 2.59

2.44

0.29

  1. CD4 + T cell decline values were limited to the range of − 50 to 50 cells/mm3 per month to exclude outliers
  2. Coeff., coefficient; SE, standard error
  3. aSERINC5 down-regulation function is expressed relative to SF2 Nef (where SF2 function is 1 in the multivariable disease progression models as previously [15, 16])
  4. bCD4 + counts are expressed per one square root unit increase
  5. cFollow-up time is expressed per day increment
  6. dViral load estimates are expressed per log10 increment
  7. eThe HPP acute infection cohort is the reference group for cohorts
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Retrovirology

ISSN: 1742-4690

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