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Fig. 4 | Retrovirology

Fig. 4

From: HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Fig. 4

The relationship between dE0/dE90 values and SERINC5 down-regulation as well as viral load set point. SERINC5 down-regulation activity of patient-derived Nef clones (expressed relative to SF2 Nef, which represents 100% activity) correlated significantly (Spearman’s correlation) with dE0 values (A) and dE90 values (B), which are proxies for overall Nef function in vivo. dE0 values were derived from the Nef fitness landscape Ising model (only the consensus amino acid present at each residue was modelled explicitly) for each Nef clone, while dE90 values were derived from the Nef fitness landscape Potts model (each amino acid present at each residue was modelled explicitly) [17]. The dE0 values (C) and dE90 values (D) also correlated significantly with viral load set point (Spearman’s correlation)

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Retrovirology

ISSN: 1742-4690

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