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Fig. 7 | Retrovirology

Fig. 7

From: A detailed analysis of F-MuLV- and SFFV-infected cells in Friend virus-infected mice reveals the contribution of both F-MuLV- and SFFV-infected cells to the interleukin-10 host response

Fig. 7

Influence of IL-10 inactivation in T cells on infectious center frequencies and splenomegaly. Tc-IL-10ko mice were infected with 500 SFFU of FV-Katushka-mTagBFP, and viral loads in the bone marrow, lymph nodes and spleen on days 4, 7, 10, 14 and 21 (A) and spleen weights (C) were analyzed. The fold-change compared to the mean viral loads (B) and mean spleen weights (D) of BALB/c mice as shown in Fig. 2 were calculated for visualization. Each dot indicates an individual mouse, bars indicate median (A) or mean values (C), the dotted line indicates the detection limit. Data from 5 (day 21), 6 (days 4, 7, 10) or 11 (day 14) mice per group were acquired in 1–3 independent experiments. Asterisk indicates statistically significant differences compared to the data of BALB/c mice as shown in Fig. 2 [data were collected side-by-side; p < 0.05, t test with Bonferroni correction for multiple comparisons (A, C)]

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Retrovirology

ISSN: 1742-4690

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